You dont get any bigger than this - the UK National Health Service go live on MOSS 2007 Web CM :
http://www.nhs.uk/
The new portal aims to empower the public to make better use of NHS services.
All content management capabilities and content searching is provided by Microsoft Office SharePoint Server 2007. The site provides geographic location of local NHS services using Microsoft Virtual Earth (http://www.nhs.uk/ServiceDirectories)
This first phase of the site, conforms to WCAG 1.0 AA (and in parts to AAA), they are going through some refinements to make it AAA compliant throughout. New and enhanced information services are being developed and will be available later in the year.
The delivery of the site involved LBi, Dr. Foster Intelligence, Department of Health and various technology partners.

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Big Bunisess with WebCMS?
Swiss Airline - www.swiss.com also running on MOSS2007
How big is the NHS Site? The current site receives on average 2 million page views an hour ... they are ready to cater for triple this when the site goes fully live.
Riaz LBi shared the accessibility learnings at a recent user group meeting.
In the meantime, have a look at this post - NHS and SharePoint
- Riaz Ahmed, Head of Microsoft Solutions, LBi
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